Functional fractionation of large-scale brain networks in the human subcortex.

ABSTRACT: Brain network mapping plays a crucial role in advancing our understanding of human brain organization and the neuroanatomic foundations of cognition. Historically, the identification of large-scale brain networks has focused on the cerebral cortex. Some cortical networks have been fractionated into subnetworks, yielding valuable insights into their domain-specific cognitive functions. In contrast, functional mapping of large-scale brain networks within subcortical regions remains an emerging and challenging field, hindered by a low signal-to-noise ratio in subcortical functional MRI data and an inability to distinguish networks with substantial spatiotemporal overlap. In this study, we fractionated and identified fifteen spatially overlapped and temporally correlated subnetworks, which can

SUBMITTER: Li J 

PROVIDER: S-EPMC12776100 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature