Skin microbiome composition and function in the development of atopic diseases during infancy.

ABSTRACT:

Background

Atopic dermatitis (AD), food sensitization (FS), and food allergy (FA) frequently co-occur in infancy, but the factors driving distinct atopic phenotypes remain unclear. While FLG null mutations are major genetic risk factors for AD, they explain only a fraction of disease heritability, suggesting a potential role for the skin microbiome.

Objective

To determine how early-life skin microbiome composition and its interaction with host genetics contribute to distinct atopic phenotypes in infancy.

Methods

We analyzed >1,000 skin swabs from 429 infants in the VITALITY cohort using deep shotgun metagenomic sequencing at 2-3 months (pre-diagnosis) and 12 months (post-diagnosis). Differential abundance, strain-level, and microbial genome-wide association ana

SUBMITTER: Shen Z 

PROVIDER: S-EPMC12776104 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature