Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.

ABSTRACT: Long-range white matter (WM) tracts support cognition by enabling communication between distant cortical regions, which are organized along a hierarchy defined by the sensorimotor-to-association (S-A) axis. However, it remains unknown how WM tracts are positioned within the cortical hierarchy to support cognition. Here, we show that WM tracts are differentially positioned in the cortical hierarchy to support specific cognitive functions, and that tracts spanning the hierarchy connect regions with greater cognitive diversity. Moreover, tracts situated within the same hierarchical level connect biologically similar regions, while those crossing the hierarchy bridge distinct biological milieux to support diverse cognitive functions. The placement of tracts in the cortical hierarchy also refle

SUBMITTER: Bagautdinova J 

PROVIDER: S-EPMC12776108 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature