Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development.

ABSTRACT: Congenital heart disease (CHD), the most common human birth defect, often results from disruptions in gene regulatory networks (GRNs) that control cardiac lineage specification and cell type identity during heart development. A conserved core set of cardiac transcription factors (TFs) orchestrates these processes through combinatorial interactions that are cell type-specific and tightly regulated across space and time. However, the genomic enhancer architecture that integrates upstream effectors to establish precise cardiac TF dosage and downstream transcriptional output remains largely unresolved. Here, we assessed the functional necessity of five developmental heart enhancer modules previously linked to the regulation of Gata4 and Hand2, core cardiac TFs exhibiting overlapp

SUBMITTER: Roland V 

PROVIDER: S-EPMC12776112 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature