Oncogene <i>c-Myc</i> Regulates Upper Respiratory Epithelial Repair for Host Immunity During Acute Influenza Infection.

ABSTRACT: The upper respiratory epithelium protects the airway from microbial exposure, environmental irritants, and viral pathogens such as influenza A virus (IAV). Situated at the airway-gastrointestinal junction, the larynx must integrate this barrier function with fine neuromuscular control under constant immune stimulation. Clinical syndromes such as post-viral vagal neuropathy-marked by chronic cough, throat clearing, dysphonia, and vocal fatigue-highlight critical gaps in our understanding of how the larynx and upper airway remodel after viral injury. To address this, we employed mouse models integrating genetics, imaging, and single-cell transcriptomics to dissect IAV-induced injury and repair in the upper respiratory tract. IAV infection displayed regionally restricted tropism toward ciliat

SUBMITTER: Foote AG 

PROVIDER: S-EPMC12776151 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature