Longitudinal Neurocognitive Trajectories in a Large Cohort of Youth Who Use Cannabis: Combining Self-Report and Toxicology.

ABSTRACT: Adolescents experience extensive neurocognitive development, which cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal Adolescent Brain Cognitive Development (ABCD) Study dataset, combining self-reported substance use with objective toxicological tests (hair, urine, breath, oral fluid). Longitudinal mixed methods of the full cohort (n=11,036, ages 9-17) investigate time-varying cannabis onset on neurocognitive performance. Secondarily, in participants with repeat toxicological hair testing (n=645) at ages 12-16, we consider

SUBMITTER: Wade NE 

PROVIDER: S-EPMC12776164 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature