Preoperative prediction of breast cancer Ki-67 status via multimodal ultrasound-clinical nomogram: a single-center study.

ABSTRACT:

Background

Breast cancer is a highly heterogeneous malignancy that poses a major health threat to women. Contemporary clinical management relies heavily on molecular subtyping, in which the Ki-67 proliferation index serves as a critical biomarker for assessing tumor aggressiveness and recurrence risk. However, conventional Ki-67 evaluation depends on invasive biopsy and immunohistochemical analysis, whose accuracy can be compromised by tumor heterogeneity-induced sampling errors and inter-observer variability. Therefore, this study aimed to develop and validate a preoperative nomogram that integrates multimodal ultrasound features with clinical parameters to enable non-invasive preoperative assessment of Ki-67 expression status in breast cancer.

Methods

We retrospectively en

SUBMITTER: Lu XK 

PROVIDER: S-EPMC12776185 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature