The prognostic role of radiotherapy in non-surgical gastric cancer: a retrospective cohort study in the SEER database.

ABSTRACT:

Background

The role of external beam radiation therapy (RT) in non-surgical gastric cancer (GC) remains controversial due to conflicting trial results and a lack of large-scale real-world evidence. This study utilizes the population-based Surveillance, Epidemiology, and End Results (SEER) database to examine the association between RT and overall survival (OS) in non-surgical GC patients, while acknowledging inherent confounding factors.

Methods

We identified 29,923 non-surgical GC patients [2004-2021] from the SEER database, categorizing them into RT (n=6,629) and non-RT (n=23,294) groups. Baseline demographic and clinicopathological characteristics were collected. Survival was followed until death or censoring. Kaplan-Meier analysis, multivariable Cox regression (adjusting

SUBMITTER: Wang M 

PROVIDER: S-EPMC12776189 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature