Impact of underlying liver etiology on post-hepatectomy survival outcomes in hepatocellular carcinoma patients.

ABSTRACT:

Background

The underlying etiology of liver disease, such as metabolic dysfunction-associated steatotic liver diseases (MASLDs) or alcohol-related liver injury, significantly affects liver function and regenerative capacity. In hepatocellular carcinoma (HCC) patients undergoing hepatectomy, these background factors may influence postoperative outcomes and long-term survival. This study aimed to evaluate the impact of different etiologies of liver disease on survival outcomes following curative hepatectomy in patients with HCC.

Methods

We retrospectively analyzed patients with HCC who underwent curative hepatectomy at two academic institutions. Background liver disease was classified according to etiology, including viral liver disease (VLD), alcohol-related liver disease (AL

SUBMITTER: Nanashima A 

PROVIDER: S-EPMC12776190 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature