SLC25A3 promotes hepatocellular carcinoma progression by inducing mitochondrial dysfunction and chromatin remodeling.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) represents one of the most life-threatening malignancies globally. Despite significant advancements in the treatment of HCC in recent years, therapeutic outcomes remain unsatisfactory, particularly for patients with advanced, inoperable HCC. Thus, there is an urgent need to identify novel therapeutic targets and develop combination therapies to enhance treatment efficacy. The aim of this study is to elucidate the role and mechanism of solute carrier family 25 member A3 (SLC25A3) in HCC.

Methods

In this study, we examined the expression profiles and prognostic implications of mitochondrial-related gene sets in HCC using data from The Cancer Genome Atlas (TCGA) database. Among these genes, SLC25A3, a mitochondrial membrane protein, was

SUBMITTER: Deng S 

PROVIDER: S-EPMC12776191 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature