Targeted next-generation sequencing reveals genomic differences between male and female breast cancer.

ABSTRACT:

Background

Compared with female breast cancer (FBC), male breast cancer (MBC) is often detected at the advanced stage and has a poorer prognosis. Due to the limited research data on MBC, its clinical diagnosis and treatment regimens are mainly based on FBC, although these regimens may not be appropriate for MBC patients. This study aimed to investigate the similarities and differences between MBC and FBC at the genetic level, in order to provide ideas and basis for the diagnosis and treatment of MBC.

Methods

In this cross-sectional study, we conducted high-throughput sequencing on formalin-fixed paraffin-embedded (FFPE) samples obtained from a cohort of 12 MBC and 14 FBC patients. Utilizing bioinformatics tools, we meticulously analyzed and compared the genomic profiles to e

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12776197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature