Interpretable LASSO-Cox model: Hsp90α/albumin ratio predicts hepatocellular carcinoma prognosis.

ABSTRACT:

Background

The heat shock protein (HSP)/albumin (ALB) ratio, which measures the levels of plasma Hsp90α to ALB, is believed to be a sensitive prognostic biomarker for hepatocellular carcinoma (HCC); however, its prognostic value has not been clearly confirmed. The aim of our study was to assess the role of HSP/ALB as a prognostic factor in patients with HCC and further establish an interpretable predictive model using least absolute shrinkage and selection operator (LASSO)-Cox regression and SHapley Additive exPlanations (SHAP) value.

Methods

A total of 1,340 HCC patients were enrolled in this study. We measured the levels of HSP/ALB in HCC patients within a week before treatment. Then, we established the HSP/ALB ratio and assessed its correlation with prognosis. Finally, we

SUBMITTER: Chen J 

PROVIDER: S-EPMC12776207 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature