Development and validation of a novel palmitoylation-related prognostic signature in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Palmitoylation, a reversible lipid modification, plays a critical role in protein trafficking and signaling and has been implicated in various cancers. However, its function in head and neck squamous cell carcinoma (HNSCC)-a highly aggressive and heterogeneous malignancy-remains largely unexplored. This study aimed to establish a prognostic model based on palmitoylation to improve risk stratification and support clinical decision-making in HNSCC patients.

Methods

The HNSCC training and validation cohorts were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO, GSE41613), respectively. A total of 4,052 palmitoylation-related genes (PRGs) were curated from the Molecular Signatures Database (MsigDB), and 282 differentially expressed PRGs we

SUBMITTER: Zhang MN 

PROVIDER: S-EPMC12776213 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature