Transfer RNA-derived fragment tRF-28-P4R8YP9LOND5 as a novel serum biomarker for gastric cancer: diagnostic efficacy and clinicopathological correlations.

ABSTRACT:

Background

The early diagnostic rate of gastric cancer (GC) is relatively low. Transfer RNA-derived fragments (tRFs), as a class of non-coding RNAs with tumor-specific expression and stability in body fluids, have emerged as highly promising diagnostic candidate biomarkers. However, their application value in GC still requires systematic validation. Therefore, this study aims to systematically evaluate the value of specific tsRNA molecules as novel diagnostic biomarkers for GC by identifying and validating them.

Methods

After identifying differentially expressed tsRNAs through the OncotRF database, the expression levels of tRF-28-P4R8YP9LOND5 were measured in serum samples from 117 GC patients, 89 healthy controls, and 51 gastritis patients using reverse transcription quanti

SUBMITTER: Gu F 

PROVIDER: S-EPMC12776215 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature