Prognostic chromatin remodeling signature stratifies survival outcomes in lung adenocarcinoma patients.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) remains a major contributor to global cancer mortality, necessitating better prognostic tools. While chromatin remodeling genes (CRGs) play a pivotal role in tumorigenesis, their clinical utility in LUAD prognostication is not well defined. This study aimed to develop and validate a robust prognostic signature based on CRGs expression to stratify LUAD patients and guide clinical decision-making.

Methods

Integrative bioinformatics analysis was conducted using transcriptomic profiles and clinical data from The Cancer Genome Atlas-LUAD and Gene Expression Omnibus cohorts. Molecular subtyping was achieved through consensus clustering, followed by survival analysis. A least absolute shrinkage and selection operator Cox regression-derived prog

SUBMITTER: Wang X 

PROVIDER: S-EPMC12776219 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature