High TERF2 expression is associated with poor prognosis and its suppression attenuates progression in acute myeloid leukemia.

ABSTRACT:

Background

Telomeric repeat-binding factor 2 (TERF2/TRF2), a core constituent of the shelterin complex that orchestrates telomere protection mechanisms, plays a pivotal role in preserving telomere structural integrity and maintaining genomic homeostasis. While dysregulated TERF2 expression has been implicated in tumorigenesis, its functional role and clinical relevance in acute myeloid leukemia (AML) remain poorly defined. Therefore, this study aimed to elucidate the functional role, underlying mechanisms, and clinical relevance of TERF2 in AML.

Methods

TERF2 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) from AML patients was quantified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Transcriptomic data from The Canc

SUBMITTER: Yao L 

PROVIDER: S-EPMC12776229 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature