An immune checkpoint-based score is a prognostic marker in retrospective cohort study of patients with gastric cancer.

ABSTRACT:

Background

Immunotherapy has emerged as an effective treatment for many cancers. However, only a proportion of gastric cancer (GC) patients can benefit from immunotherapy. Thus, assessing different immune checkpoints, which regulate T-cell activation and function, is critical. This study aimed to explore the role of the six immune checkpoints, including B7-H3, B7-H4, PD-L1, PD-1, VISTA, and TIGIT, in GC.

Methods

The expression patterns of the six immune checkpoints in 478 GC patients were evaluated by immunohistochemistry. The relationships between immune checkpoints, clinicopathological features, and overall survival (OS) were analyzed.

Results

The positivity rates for B7-H3 in tumor cells (TCs) and stromal cells (SCs), B7-H4 in TCs, PD-L1 in TCs and SCs, PD-1 in imm

SUBMITTER: Lu Z 

PROVIDER: S-EPMC12776231 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature