Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.

ABSTRACT:

Background

Coronary heart disease (CHD) is a leading cause of cardiovascular mortality worldwide, with its pathogenesis being complex and not yet fully understood. The rapid development of genomics, especially in epigenetic research, has provided essential tools for identifying new pathogenic targets. This study is aimed at systematically exploring the molecular mechanisms of CHD using protein quantitative trait locus (pQTL) data and multiomics Mendelian randomization (MR) approaches, with a specific focus on the epigenetic regulation of the key gene ITGB7.

Methods

The study first integrated 1812 cis-pQTL data with CHD GWAS data to perform a two-sample MR analysis, identifying protein-coding genes significantly associated with CHD. Transcriptomic data were then used t

SUBMITTER: Guo J 

PROVIDER: S-EPMC12776257 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature