Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors in <i>Chlamydia</i>.

ABSTRACT: Chlamydia trachomatis is a leading cause of urogenital infections that can result in serious long-term complications. This obligate intracellular bacterium undergoes a biphasic developmental cycle alternating between the infectious elementary body and the replicative reticulate body and can enter a persistent state in response to adverse environmental conditions. Although transcriptomic reprogramming is central to chlamydial stress adaptation and persistence, how responses differ across biologically distinct stressors remains incompletely defined. Here, we performed a comparative reanalysis of five published, high-quality C. trachomatis RNA-Seq datasets generated under prolonged interferon-γ treatment, tryptophan starvation, iron starvation, penicillin exposure, or acute heat

SUBMITTER: Haines R 

PROVIDER: S-EPMC12776308 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature