Identification and Regulation of a Hepatic Lipogenic Metabolon.

ABSTRACT: De novo lipogenesis (DNL) plays a key role in the excessive fat accumulation present in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Most mechanistic studies and experimental strategies for improving hepatic steatosis in MASLD have focused on the transcriptional regulation of enzymes involved in DNL and triglyceride (TG) synthesis. Here, we provide evidence for a post-translational mechanism that enhances fatty acid (FA) and TG synthesis through the assembly of a multi-protein lipogenic metabolon in liver. Under anabolic conditions, acetyl-CoA carboxylase 1 (ACC1) interacts with additional key enzymes in the DNL and TG synthesis pathway. Immunofluorescence and electron microscopy reveal that this lipogenic metabolon localizes around lipid droplets (LDs) and in proximit

SUBMITTER: Zhu X 

PROVIDER: S-EPMC12776311 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature