Huntingtin in the amygdaloid basolateral complex is correlated with Vonsattel staging in Huntington's disease.

ABSTRACT: Huntington's disease has traditionally been considered a motor disorder, but it is currently classified as a multisystem neurodegenerative disease that involves brain regions, such as the amygdala, and causes depression. The aim of the present study was to analyse the distribution of huntingtin in the human amygdaloid basolateral complex, considering its nuclei, sex, triplet repeats and Vonsattel score, as well as to characterize the cellular relationships between huntingtin and associated copathologies. The present study included 23 human brain samples from patients (males and females) with and without Huntington's disease, Parkinson's disease and Alzheimer's disease. An unbiased stereology approach was used to quantify huntingtin deposits. Multiple immunofluorescence experiments were con

SUBMITTER: Sanchez-Migallon P 

PROVIDER: S-EPMC12776364 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature