Steroid hormone-dependent glial-neuronal interaction promotes brain development during <i>Drosophila</i> metamorphosis.

ABSTRACT: Steroid hormones regulate various aspects of brain development in metazoans. In the fruit fly Drosophila melanogaster, the primary steroid hormone ecdysone enters the central nervous system (CNS) via Ecdysone Importer (EcI) in the blood-brain barrier (BBB) and induces brain development during metamorphosis. However, our understanding of the exact cell types that require ecdysone during CNS transformation is still limited. Here, we report that ecdysone-dependent glial-neuronal interaction promotes brain development during Drosophila metamorphosis. Unexpectedly, disrupting ecdysone signaling in glial cells caused more severe defects in CNS transformation than in neurons, suggesting an essential role of glia in ecdysone-dependent brain development. When ecdysone receptor

SUBMITTER: Imura E 

PROVIDER: S-EPMC12776432 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature