Towards an evolutionary baseline model of <i>Plasmodium falciparum</i> for population-genomic inference.

ABSTRACT: Malaria has caused over 15.7 million deaths in the 21^st century and was responsible for ~600 thousand deaths globally in 2023 alone. Although many effective antimalarial drugs have been developed and widely adopted to reduce the occurrence and severity of the disease, recurrent resistance to the frontline treatment has been of major concern. Multiple drug resistance alleles at intermediate and high allele frequency have been identified in specific Asian and African populations of P. falciparum, the deadliest malaria parasite. With the improvement in throughput of sequencing technologies and global efforts such as the MalariaGEN project to build genomic surveillance, we now have access to tens of thousands of genomes of P. falciparum from across the world. With this

SUBMITTER: Henry CM 

PROVIDER: S-EPMC12776459 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature