Cyfip2 mediates sensorimotor integration of visual input through Rac1-dependent actin remodeling.

ABSTRACT: Sensorimotor integration of visual input is essential for adaptive behaviors such as navigation, hunting, and escape from danger, yet our understanding of the developmental mechanisms that assemble these visuomotor circuits remains incomplete. Cytoplasmic FMRP-interacting protein 2 (cyfip2) is a key factor in retinotectal axon guidance in zebrafish larvae, and it has conserved roles in regulating actin dynamics and mRNA translation. Variants in human CYFIP2 cause neurodevelopmental disabilities including vision deficits, but how it functions to shape visually-driven behavior is unclear. Here we measured multiple visually-mediated behaviors, brain-wide activity, and conditional rescue of behavioral defects in larval zebrafish to define cyfip2's roles in assembling visua

SUBMITTER: Charron KM 

PROVIDER: S-EPMC12776461 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature