Controlled intra- and extracellular localization of bioorthogonal polymeric nanozymes.

ABSTRACT: Bioorthogonal chemistry enables non-native chemical reactions to occur within complex biological environments. Transition metal catalysts mediate bioorthogonal uncaging reactions, allowing for the localized activation of chemically caged drug molecules. The ability to perform uncaging reactions selectively intra- or extracellularly expands the bioorthogonal toolkit by fine-tuning the localization of drug activation. However, transition metal complexes can diffuse through the cell membrane and, therefore, often lack control over intra- or extracellularly localized catalysis. Amphiphilic polymer nanoparticles can encapsulate transition metal catalysts, creating "polyzymes". The polymer nanoscaffolds can be engineered to localize intra- or extracellularly by decorating the nanoparticle surfac

SUBMITTER: Hirschbiegel CM 

PROVIDER: S-EPMC12776530 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature