Enhanced Osteogenic and Neurogenic Differentiation of Dental Pulp Stem Cells by Micro-Current Stimulation and Chitosan-Poly(Ethylene Glycol) Blended Calcium Phosphate Cement.

ABSTRACT: Bioelectricity plays multiple roles in the human body, including cellular signaling and molecular-level expression. It can be hypothesized that applying microcurrent to the human body can induce physiological change, optimally producing desired therapeutic effects. In this research, we developed an indium tin oxide (ITO) conductive glass-based microcurrent stimulation (MCS) device incorporating chitosan-poly(ethylene glycol) blended calcium phosphate cement (CS/PEG-CPC) to ultimately regenerate dental pulp by simultaneously differentiating dental pulp stem cells (DPSCs) into osteogenic and neurogenic tissues. To optimize accurate MCS parameter for desired DPSC differentiation, various parameters including pulse type, treatment duration, frequency, intensity, pulse duration were determined

SUBMITTER: Kim JE 

PROVIDER: S-EPMC12776575 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature