Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase.

ABSTRACT: The order Bunyavirales encompasses a diverse group of segmented negative-sense RNA viruses, many of which can cause severe human disease. Their global distribution paired with multiple routes of transmission by arthropods and rodents cause risks to public health. However, effective antiviral drugs are not yet approved. Molnupiravir is an orally available prodrug of β-D-N⁴-hydroxycytidine (NHC) and shows a broad spectrum of antiviral activity. This includes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and also several members of the Bunyavirales, such as Crimean-Congo hemorrhagic fever virus (CCHFV). For SARS-CoV-2, the active triphosphate form of NHC (NHC-TP) targets the viral RNA-dependent RNA polymerase (RdRp) and causes lethal mutagenesis; howeve

SUBMITTER: Sloan A 

PROVIDER: S-EPMC12776605 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature