Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.

ABSTRACT:

Significance

Our landmark discovery of viral mimicry characterized repetitive elements as immunogenic stimuli that cull cancer cells. If expressed repetitive elements cull cancer cells, why does every human cancer express repetitive elements? Our report offers an exciting advancement toward understanding this paradox and how to exploit this mechanism for cancer interception. See related commentary by Murayama and Cañadas, p. 670.

SUBMITTER: Ishak CA 

PROVIDER: S-EPMC12776606 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature