Adenovirus 40 and 41 Antibodies Associated With Protection From Infection in a Bangladeshi Birth Cohort.

ABSTRACT:

Background

Adenovirus (AdV) 40/41 is a major cause of pediatric acute gastroenteritis (AGE), leading to significant morbidity and mortality worldwide. As little is known about clinical correlates of protection, we analyzed AdV-specific antibody reactivities using a multi-AdV protein microarray and serum from a Bangladeshi birth cohort surveilled for diarrhea during the first 2 years of life.

Methods

Arrays contained a comprehensive set of proteins from AdV 40 and 41, in addition to respiratory AdVs 4, 5, and 26. Children were split into four groups according to AdV 40/41 infection occurrence during year 1 (Y1) and year 2 (Y2) of life. One-year array antibody reactivity levels were analyzed from 119 children using principal component analysis (PCA). Top antibody reactivities

SUBMITTER: Hendrick J 

PROVIDER: S-EPMC12776611 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature