Structurally and functionally optimized silk fibroin-alginate-based biomimetic scaffolds reinforced with nanobioceramics for bone tissue engineering applications.

ABSTRACT: In this study, we prepared chemically crosslinked silk fibroin (SF) and sodium alginate (Alg) biomimetic scaffolds reinforced with bioceramic nanohydroxyapatite (nHAp) for bone tissue engineering (BTE) applications. The pore sizes of these scaffolds were effectively controlled by varying the composition of the SF/nHAp/Alg biocomposites. The scaffold prepared with a 40:20:40 SF: nHAp: Alg ratio exhibited excellent swelling properties, reaching over 1700% within 70 min. In vitro degradation studies demonstrated that these biomimetic scaffolds exhibited controlled degradation, taking over 30 days to achieve 50% degradation. The scaffolds also showed good mechanical properties; they maintained structural integrity and did not break, even under a load approximately 800 times their own weight. A

SUBMITTER: Nguyen TN 

PROVIDER: S-EPMC12776982 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature