Exercise intervention regulates gut microbiota to improve type 2 diabetes: a narrative review of the mechanisms.

ABSTRACT:

Background

The gut microbiota is increasingly recognized as a key factor in the pathogenesis of type 2 diabetes mellitus (T2DM). Concurrently, exercise intervention has emerged as a promising non-pharmacological strategy for T2DM management, potentially mediated through gut microbiome modulation.

Methods

This narrative review searched Web of Science, PubMed, and Embase for literature published from 1992 to the present, ultimately including 58 relevant publications. The focus was on elucidating the physiological mechanisms by which exercise modulates gut microbiota to ameliorate T2DM.

Results

Our synthesis indicates that exercise training beneficially alters gut microbiota composition and function, which in turn enhances systemic insulin sensitivity and improves metabo

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12777083 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature