Childhood obesity and DNA methylation in an epigenome-wide association study: findings from the Hokkaido Birth Cohort.

ABSTRACT:

Background

Childhood obesity is a pressing public health and pediatric issue. Recently, epigenome-wide association study (EWAS) has received increasing research attention and revealed the association between cord blood methylation and pediatric health problems. However, the relationship between cord blood DNA methylation and childhood obesity remains incompletely understood. This study aimed to assess cord blood DNA methylation and its association with childhood obesity using an EWAS.

Results

The present study included 12-year-old children with obesity and control participants from the Hokkaido Study on Environment and Children's Health (the Hokkaido cohort), a prospective birth cohort study. The Hokkaido cohort study collected participants' cord blood samples at birth, whic

SUBMITTER: Iwata H 

PROVIDER: S-EPMC12777100 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature