Low prognostic nutritional index is highly associated with periprosthetic joint infection in revision arthroplasty: a 14-year retrospective cohort study.

ABSTRACT:

Background

The relationship between preoperative nutritional status and periprosthetic joint infection (PJI) remains unclear in patients undergoing revision arthroplasty. This study aimed to investigate (1) whether preoperative nutritional status influences the risk of PJI in these patients, and (2) to determine the optimal threshold for risk stratification.

Methods

A retrospective cohort study involved 1,117 patients who underwent hip or knee revision between January 2011 and September 2024. Prognostic nutritional index (PNI) was calculated based on serum albumin and lymphocyte counts. Multivariate logistic regression, propensity score matching (PSM), restricted cubic spline (RCS) modeling, and Kaplan-Meier analysis were used to assess the association between PNI and PJI.

SUBMITTER: Chen X 

PROVIDER: S-EPMC12777145 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature