Leveraging two novel droplet-based single-cell RNA Sequencing platforms: a comparative study with 10x genomics.

ABSTRACT:

Background

Currently, single cell transcriptome profiling technology is gaining popularity, with an increasing number of novel platforms emerging. The development of new technologies is aimed at improving data quality, scale, cost, or labor intensity. Given the rapid evolution of these technologies, a comprehensive and independent comparison of platforms is crucial to identify the most suitable one for studying various biological objects and achieving specific experimental goals.

Results

Here we performed a comparison of two droplet-based high-throughput single-cell platforms, namely, SeekOne and MobiDrop with a widely-used commercial platform from 10× Genomics. The use of different types of samples allowed us to evaluate the performance of the platforms on cell suspensions

SUBMITTER: Maluchenko AV 

PROVIDER: S-EPMC12777333 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature