Clinical, radiological, and pathological characteristics and long-term outcomes of silent corticotroph adenomas: a retrospective study.

ABSTRACT:

Background

Silent corticotroph adenomas (SCAs), a subtype of non-functioning pituitary adenomas (NFPAs), exhibit aggressive biological behaviour despite the absence of clinical hormone hypersecretion. This study aimed to identify preoperative predictors of SCAs and evaluate prognostic factors for postoperative recurrence in both NFPAs and SCAs.

Methods

We retrospectively analysed 192 patients with NFPAs who underwent transsphenoidal surgery between 2014 and 2019. Clinical presentation, imaging findings, pathological characteristics, surgical outcomes, and recurrence data were compared. Logistic regression and receiver operating characteristic analyses were used to identify predictors of SCAs. Recurrence-free survival was assessed using Kaplan-Meier analysis, and Cox regressi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12777387 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature