PotD contributes to Streptococcus suis-induced blood-brain barrier disruption by regulating arcA transcription.

ABSTRACT: The ABC transporter substrate-binding protein PotD plays an important role in bacteria for polyamine uptake, but its role in the pathogenicity of Streptococcus suis (S. suis) in the host is still unknown. Our study investigated the mechanism by which PotD mediates S. suis pathogenicity, especially S. suis-induced blood-brain barrier (BBB) disruption. The results showed that ΔpotD mutant significantly reduced biofilm formation and bacterial load in different tissues, including brain, blood, liver, and lung. Importantly, knockout of potD significantly improved mouse survival rate, indicating that PotD is involved in S. suis pathogenicity. The deletion of potD significantly reversed the reduction of tight junction proteins ZO-1 and Occludin in mouse brain and human cerebral microvascular endo

SUBMITTER: Lang S 

PROVIDER: S-EPMC12777399 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature