Predictive value of tumor marker index for pathological complete response following neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

ABSTRACT:

Background

Pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) is associated with favorable outcomes; however, pre-treatment biomarkers that reliably predict pCR remain limited. We evaluated whether the Tumor Marker Index (TMI; geometric mean of normalized CEA and CA19-9) predicts pCR and examined its relationship with recurrence and survival.

Methods

This single-center retrospective study included 123 stage III LARC patients treated with nCRT followed by total mesorectal excision (2015-2022). The primary endpoint was pCR (ypT0N0). Secondary endpoints were progression-free survival (PFS) and overall survival (OS). Receiver operating characteristic (ROC) analysis assessed TMI discrimination and identified a

SUBMITTER: Bayram S 

PROVIDER: S-EPMC12777407 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature