Edentulism as an independent risk factor for sarcopenia: evidence from cross-sectional and longitudinal analyses based on the CHARLS cohort.

ABSTRACT:

Background

Edentulism and sarcopenia are two highly prevalent, age-related conditions that share common nutritional, inflammatory, and functional pathways. Whether tooth loss independently contributes to the development of sarcopenia-and in which population strata this effect is strongest-remains uncertain, especially in Asian cohorts.

Methods

We analysed 17,099 participants (baseline 2011) from the China Health and Retirement Longitudinal Study (CHARLS). Sarcopenia was defined by Asian Working Group for Sarcopenia 2019 criteria. Multivariable logistic models were fitted for cross-sectional analysis (wave 1). For longitudinal analysis (waves 1-3, seven-year follow-up), Cox proportional hazards models were fitted as the primary analysis, with logistic regression models applie

SUBMITTER: Zhai T 

PROVIDER: S-EPMC12777434 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature