Antimicrobial peptides derived from human ameloblastin targeting biofilms.

ABSTRACT: Oral biofilm-related diseases, such as dental caries and periodontitis, remain among the most prevalent global health issues and are increasingly complicated by antibiotic resistance and biofilm persistence, which limit the effectiveness of conventional treatments. This study addresses the challenges by exploring antimicrobial peptides (AMPs) derived from ameloblastin (AMBN), a protein integral to dental biomineralization and categorized as an intrinsically disordered protein. In humans, the AMBN gene encodes two isoforms, ISO I and ISO II, with distinct but not fully understood functions. Four AMBN ISO I-derived peptides (A, Am, B, Bm) were designed, synthesized, and tested for antimicrobial and antibiofilm activity. Peptides A and Am moderately inhibited biofilms of E. faecalis, S. aureu

SUBMITTER: Vetyskova V 

PROVIDER: S-EPMC12777444 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature