Diagnostic accuracy of serological tests for dermatitis herpetiformis: systematic review and Bayesian meta-analysis.

ABSTRACT:

Background

The diagnosis of Dermatitis Herpetiformis (DH) relies on both clinical and serological tests. Accurate diagnostic tools are critical for effective management. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of serological tests for DH, focusing on the impact of gluten-free diet (GFD) status on test performance, using Direct Immunofluorescence (DIF) as the reference standard.

Methods

This review follows the PRISMA-DTA guidelines. The PICO framework was used to define the review question. Databases, including PubMed, SCOPUS, EMBASE, and Web of Science were comprehensively searched until July 14, 2023. The risk of bias was assessed using QUADAS-2. Bayesian meta-analyses were conducted using the MetaBayesDTA tool.

Results

A to

SUBMITTER: Ocagli H 

PROVIDER: S-EPMC12777455 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature