Oil-based and oil-free formulations for enhancing cannabidiol bioavailability.

ABSTRACT:

Background

Cannabidiol (CBD) exhibits therapeutic potential due to its analgesic, anxiolytic, anti-inflammatory, and anticonvulsant effects. However, its oral bioavailability is limited by poor water solubility and extensive first-pass metabolism. Formulation strategies such as oil-based emulsions and oil-free particles may overcome these limitations by enhancing solubilization and promoting lymphatic absorption. This study aimed to evaluate the effects of oil droplet and particle size, and surfactant concentration on CBD bioavailability.

Methods

CBD emulsions were produced using membrane emulsification, high-pressure homogenization, while particles were produced via solvent emulsification-evaporation method. Physicochemical properties were assessed using microscopy and ligh

SUBMITTER: Jelinek P 

PROVIDER: S-EPMC12777474 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature