Honokiol attenuates diabetic nephropathy by targeting SIRT3 to suppress mitochondrial ROS-induced pyroptosis.

ABSTRACT:

Background

Diabetic nephropathy (DN) persists as the leading cause of end-stage renal disease worldwide. Growing evidence indicates that mitochondrial dysfunction triggers NLRP3 inflammasome activation and subsequent pyroptosis, which play crucial roles in DN development. Honokiol (HKL), a natural compound with the ability to upregulate SIRT3 expression, shows promise in protecting mitochondrial function. This study investigates HKL's renoprotective effects in DN and explores its mechanism of action through the SIRT3-mediated regulation of mitochondrial ROS, NLRP3 inflammasome, and pyroptosis.

Materials and methods

db/db diabetic mice and HK-2 cells subjected to hyperglycemic stimulation were used to assess the therapeutic effects of HKL. Renal function, pyroptosis, and mito

SUBMITTER: Yu K 

PROVIDER: S-EPMC12777499 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature