Strategic trimodal therapy enhances radiation-induced abscopal response in renal cancer.

ABSTRACT:

Background

The abscopal effect, tumor regression at distant, non-irradiated sites following localized radiotherapy, is rarely observed, even in immunogenic cancers such as renal cell carcinoma. Current strategies have largely failed to reliably enhance this phenomenon. This study aimed to develop and evaluate a novel therapeutic approach to potentiate the abscopal effect using a combination of tumor-targeted liposomal everolimus and YM155 (EY-L), radiation, and interleukin-2 (IL-2).

Methods

A trimodal therapy comprising EY-L, localized radiation, and systemic IL-2 was tested in two murine renal cancer models (Renca and LVRCC67) using a bilateral tumor setup to distinguish local and distant tumor responses. The efficacy of the triple therapy was compared to that of single and

SUBMITTER: Rachamala HK 

PROVIDER: S-EPMC12777502 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature