Serum Haptoglobin as a Predictor of Treatment Response in Patients With Chronic Spontaneous Urticaria.

ABSTRACT:

Background

Chronic spontaneous urticaria (CSU) is a mast cell-driven disease associated with systemic inflammation and altered immune responses. Haptoglobin (HP), an acute-phase glycoprotein, exhibits antioxidative and immunomodulatory properties, while zonulin, the precursor of HP-2, regulates epithelial barrier integrity. We investigated the clinical relevance of serum HP and zonulin in CSU and their association with treatment outcomes.

Methods

Serum HP and zonulin levels were measured by ELISA in 124 CSU patients and 57 healthy controls (HCs). In 62 CSU patients, follow-up samples were obtained after 3 months of treatment. Clinical outcomes included the urticaria activity score over 7 days (UAS7) and the urticaria control test (UCT).

Results

Serum HP levels were si

SUBMITTER: Park KW 

PROVIDER: S-EPMC12777545 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature