Impact of <i>Pseudomonas aeruginosa</i> biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity.

ABSTRACT: Multidrug-resistant Pseudomonas aeruginosa is a leading cause of hospital-acquired infections, including medical device infections, partially due to the organism's ability to produce biofilm on prosthetic material. Increased antibiotic tolerance of bacteria within biofilm, along with the increasing prevalence of infections caused by multidrug-resistant P. aeruginosa, including extensively drug-resistant phenotypes, results in scenarios where conventional antibiotics may fail to effectively treat these infections. Bacteriophage (phage) therapy is a promising alternative to conventional antimicrobial therapy that can provide potent antibiofilm activity, particularly when combined with antibiotics. The impact of P. aeruginosa biofilm phenotype on the efficacy of phage-ant

SUBMITTER: Van Helden SR 

PROVIDER: S-EPMC12777554 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature