A patient-centric paradigm and tool for clinical research: the DOOR is open.

ABSTRACT: Randomized clinical trials are the gold standard for evaluating the benefits and harms of interventions and yet may not provide the evidence needed to inform medical decision-making, an ultimate goal for clinical research. Commonly used design and analysis approaches are often not suited to answer the most important questions to inform clinical practice, specifically how do resulting patient experiences, when comprehensively considering benefits and harms, compare between therapeutic alternatives? The standard approach of siloed analysis of one outcome at a time: (i) does not incorporate associations between multiple outcomes; (ii) does not recognize the cumulative nature of multiple outcomes in individual patients or recognize important gradations of global patient response; (iii) suffers

SUBMITTER: Hamasaki T 

PROVIDER: S-EPMC12777562 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature