Impact of a GABA-Producing <i>Lactococcus lactis</i> on Microbiota and Mycobiota During CNS Inflammatory Demyelination.

ABSTRACT: Gut microbes are key regulators of immune homeostasis. Their composition fluctuates over time and between individuals and is also influenced by disease. We and others have reported changes in gut bacterial composition following induction of experimental autoimmune encephalomyelitis (EAE), a well-established model for multiple sclerosis (MS). Specifically, we observed reductions in the abundance of bacteria capable of producing gamma-aminobutyric acid (GABA). Because GABA regulates immune cell function, we genetically engineered a Lactococcus lactis strain to overproduce GABA (P8s-GAD L. lactis) and hypothesized that this strain would have protective activity in EAE. To test this hypothesis, a suspension of P8s-GAD L. lactis was administered by gavage to C57BL/6 Envigo

SUBMITTER: Hill K 

PROVIDER: S-EPMC12777695 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature