Assessment of sub-chronic toxicity and anti-aging effects of a solid self-microemulsifying drug delivery system of <i>Kaempferia parviflora</i> extract in a D-galactose-induced rat model.

ABSTRACT:

Context

The pharmacological effects of Kaempferia parviflora have been extensively documented. A solid self-microemulsifying drug delivery system (SMEDDS) has been developed to address limitations such as poor water solubility and low bioavailability.

Objective

This study evaluated the safety and anti-aging efficacy of the solid SMEDDS containing K. parviflora extract (KPS-SMEDDS) in rats.

Materials and methods

A sub-chronic toxicity study was performed to assess the safety of KPS-SMEDDS. Healthy rats (n = 10/group) received oral doses of 125, 250, or 500 mg/kg body weight daily for 90 days. Clinical signs, body weight, hematological and biochemical parameters, and major organ histopathology were evaluated. Separately, the anti-aging effects of KP

SUBMITTER: Somintara S 

PROVIDER: S-EPMC12777754 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature