Long non-coding RNA NEAT1 mediated lupus nephritis induced podocytes pyroptosis through DNMT1-STING axis.

ABSTRACT: Lupus nephritis (LN), a severe complication of systemic lupus erythematosus, is characterized by podocyte injury mediated through autoantibody deposition, yet the underlying mechanisms remain incompletely understood. This study investigated the role of long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) in podocyte pyroptosis and its interaction with the stimulator of interferon genes (STING) pathway. Using peripheral blood mononuclear cells (PBMCs) and IgG isolated from 25 LN patients and 20 healthy controls, we found NEAT1 expression was significantly elevated in LN patient PBMCs and confirmed this in MRL/lpr mice. In vitro experiments demonstrated that LN-IgG treatment induced dose-dependent podocyte pyroptosis in human podocytes, an effect enhanced by NEAT1 overex

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC12777783 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature