Xijiaqi Formula attenuates myocardial infarction-induced chronic heart failure by inhibiting TGF-β1/Smads-mediated fibroblast activation.

ABSTRACT:

Context

Chronic heart failure (CHF) is the common concern following myocardial infarction. Xijiaqi Formula (XJQ) effectively treats CHF clinically while the underlying mechanism remains unclarified.

Objective

This study was designed to investigate the effect and mechanism of XJQ on CHF in rats following MI.

Materials and methods

UHPLC-Q-TOF-MS/MS was utilized to analyze the constituents of XJQ. Post-MI CHF was induced in rats by permanent ligation of the left anterior descending coronary artery. Cardiac function was assessed by echocardiogram and hemodynamic. Myocardial morphology, fibrosis, and ultrastructure were evaluated through HE staining, Masson staining, and transmission electron microscopy, respectively. Myocardial transcriptomics were employed to identify ge

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12777859 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature